Description of Illness: Monkeypox is a rare but potentially serious viral illness. Although infection may begin with fever, headache, muscle aches, and exhaustion before the development of rash, many of the cases associated with the 2022 outbreak have reported very mild or no symptoms other than rash. In some cases, rash and lesions have been limited to the genitourinary area. The characteristic lesions are deep-seated, vesicular or pustular with a centrifugal distribution; the lesions are well circumscribed and often umbilicate or become confluent, progressing over time to scabs. The rash can be disseminated. The illness typically lasts for 2-4 weeks.