Enterobacterales, Carbapenem Resistant

Enterobacterales, Carbapenem Resistant 

TEST NAME

Enterobacterales - Carbapenem Resistant

DISEASE/DISORDER Carbapenem Resistant Enterobacterales 
ALTERNATE NAME(S) CRE 
METHODOLOGY MALDI-TOF,  PCR,  Antibiotic susceptibility testing, mCIM 
SPECIAL INSTRUCTIONS
  • Isolate submission REQUIRED 
  • Include susceptibility test results, if available
ORDERING INFORMATION TDOH ARLN Lab Web Portal

Specimen Requirements


Patient Preparation
  • None
Specimen Collection
  • For laboratories able to test for carbapenemase production or carbapenemase-producing genes, report any organism with either of the following:

-Detection of carbapenemase production

-Detection of at least one carbapenemase-producing gene

  • If detected via NAAT, perform culture to obtain an isolate for subsequent testing to determine the antibiotic susceptibility profile
  • For laboratories unable to test for carbapenemase production or carbapenemase-producing genes, report these organisms and resistance scenarios:

-Enterobacterales order: Proteus species, Providencia species, and   Morganella morganii with intermediate or resistant interpretations to   ertapenem, meropenem, or doripenem

  • All other Enterobacterales bacteria with resistant interpretation to at least one carbapenem antibiotic
Specimen Labeling
  • Specimen must be labeled with at least two unique patient identifiers and match the accompanying TNDOH ARLN Lab Web Portal.
Specimen Processing
  • None
Specimen Storage and Preservation
  • Store specimens at ambient temperature until shipment.
Specimen Transportation
  • Ship specimens at ambient temperature.
  • All infectious substance shipments must conform to U.S. Department of Transportation (DOT) Hazardous Materials Regulations (HMR 49 C.F.R. Parts 171-180). 
Specimen Acceptability and Rejection
  • Only pure cultures will be accepted for testing. 
  • Mixed cultures will be rejected.
  • Specimens that are mislabeled will be rejected.
  • Specimens that are broken in transit will be rejected.
  • Specimens received that do not meet the specimen requirements outlined in the Directory of Services or that deviate from the special instructions will not be acceptable for testing.
Testing Location
  • Nashville

This Page Last Updated: September 15, 2025 at 2:43 PM